The Unit for Clinical Systems Biology (UCSB)/Unit for Paediatric Allergology (UPA), Queen Silvia Children's Hospital, Göteborg, Sweden.

Organization and funding: The UCSB is part of the Centre for Systems Biology in Göteborg, which links several groups within the medical, natural science and technological faculties. This local network extends internationally through EC funded projects with a total budget of 15 million Euro. The UCSB is supported by the Swedish Research Council, the European Commission and Göteborg University. The total funding is some 2 million Euro over the next three years. Key investigators and their roles: Mikael Benson is the coordinator of the project and the head of the UCSB. He and co-workers are responsible for gathering the clinical materials and performing the experimental and genomic studies in collaboration with the UPA, the Department of Immunology and the Bio-X-Med genomics unit, as well as with the applicants in WP3 and WP5. MB is a senior consultant in pediatric allergology at the UPA. He has a six-year grant as a senior researcher from the Swedish Research Council to apply high-throughput technology and systems biology to find markers for personalized medication.

Five relevant publications
  1. Benson M, Langston MA, Adner M, Andersson B, Torinssson-Naluai A, Cardell LO. A network-based analysis of the late-phase reaction of the skin. The Journal of Allergy and Clinical Immunology 2006;118(1):220-5.
  2. Benson M, Carlsson L, Guillot G, et al. A network-based analysis of allergen-challenged CD4+ T cells from patients with allergic rhinitis. Genes and immunity 2006;7(6):514-21
  3. Benson M, Breitling R. Network theory to understand microarray studies of complex diseases. Current Molecular Medicine 2006;6(6):695-701
  4. Benson M, Carlsson L, Adner M, et al. Gene profiling reveals increased expression of uteroglobin and other anti-inflammatory genes in glucocorticoid-treated nasal polyps. The Journal of Allergy and Clinical Immunology 2004;113(6):1137-43
  5. Benson M, Carlsson B, Carlsson LM, et al. DNA microarray analysis of transforming growth factor-beta and related transcripts in nasal biopsies from patients with allergic rhinitis. Cytokine 2002;18(1):20-5

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